Dr Terry Gaymes

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Terry Gaymes
About
Teaching and learning
Research

About

I graduated from the University of Wolverhampton with a Biomedical Sciences degree and went on to study for a DPhil in Biochemistry at the University of Sussex. My DPhil research investigated the modes of action of novel immunosuppressants. I then worked as a post doctoral researcher at Kings College London (KCL) where I investigated the mechanisms of genomic instability in myeloid malignancies, in particular the adaptations in DNA repair that propagate chromosomal rearrangements in myeloid leukaemia. I took up my position of Lecturer in Haematology and Immunology here at Kingston Universityin 2016. In my ongoing research, I continue to investigate DNA damage and repair changes biomarkers in leukaemia that can be exploited therapeutically.

Academic responsibilities

Senior lecturer in Haematology and Immunology

Qualifications

  • DPhil Biochemistry (University of Sussex)
  • BSc (Hons) Biomedical sciences (University of Wolverhampton)
  • Fellow of the Higher Education Authority (FHEA)

Teaching and learning

Undergraduate courses taught

Research

DNA is continually exposed to exogenous and endogenous insults. Genomic integrity is maintained in the cell by a number of well-defined repair mechanisms including the double strand break (DSB) repair pathways of homologous recombination and non-homologous end-joining (NHEJ). However, defects in DNA repair can result in the improper repair of DNA damage and an increased propensity to cancer.I have previously showed that myeloid leukaemic cells and chromosomal instability syndromes demonstrated up-regulated and erroneous NHEJ repair activity as a result of constitutive DNA damage. We have realised that genetic defects in the pathways of DSB DNA repair and other DNA damage response pathways would render tumour cells sensitive to DNA repair inhibitors such as Poly ADP ribose polymerase (PARP)inhibitors. Previously, trialled in breast cancer these agents have demonstrated beneficial therapeutic responses in more than 60 clinical trials. The future aims are to investigate and identify biomarkers in Leukaemia that would identify patients for PARP inhibitor therapy. Furthermore, could one further exploit DNA repair anomalies with other agents in Leukaemia for therapeutic intervention

Research student supervision

Main supervision

Other supervision

Publications

Jump to: Article | Book Section | Conference or Workshop Item
Number of items: 16.

Article

Gopal, Ajay K, Popat, Rakesh, Mattison, Ryan J, Menne, Tobias, Bloor, Adrian, , Khwaja, Asim, Juckett, Mark, Chen, Ying, Cotter, Matthew J and Mufti, Ghulam J (2021) International Journal of Hematologic Oncology, 10(3), IJH35. ISSN (print) 2045-1393

, Mohamedali, Azim, Eiliazadeh, Anthony L., Darling, David and Mufti, Ghulam J. (2017) Cancer Research, 77(7), pp. 1697-1708. ISSN (print) 0008-5472

Mohamedali, A M, Gaken, J, Ahmed, M, Malik, F, Smith, A E, Best, S, Mian, S, , Ireland, R, Kulasekararaj, A G and Mufti, G J (2015) Leukemia, 29(9), pp. 1928-1938. ISSN (print) 0887-6924

, Mohamedali, Azim M., Patterson, Miranda, Matto, Nazia, , Kulasekaraj, Austin, Chelliah, Rajani, Curtin, Nicola, Farzaneh, Farzin, Shall, Sydney and Mufti, Ghulam J. (2013) Haematologica, 98(9), pp. 1397-1406. ISSN (print) 0390-6078

Orr, S J, , Ladon, D, Chronis, C, Czepulkowski, B, Wang, R, Mufti, G J, Marcotte, E M and Thomas, N S B (2010) Oncogene, 29(26), pp. 3803-3814. ISSN (print) 0950-9232

, Shall, Sydney, MacPherson, Lee J., Twine, Natalie A., Lea, Nicholas C., Farzaneh, Farzin and Mufti, Ghulam J. (2009) Acta Haematologica, 94, pp. 638-646. ISSN (print) 0001-5792

, Shall, Sydney, Farzaneh, Farzin and Mufti, Ghulam J. (2008) Haematologica, 93, pp. 1886-1889. ISSN (print) 0390-6078

Ranuncolo, Stella Maria, Wang, Ling, Polo, Jose M., Dell'Oso, Tania, Dierov, Jamil, , Rassool, Feyruz, Carroll, Martin and Melnick, Ari (2008) The Journal of Biological Chemistry, 283(33), pp. 22565-22572. ISSN (print) 0021-9258

Rassool, Feyruz, , Omidvar, Nader, Brady, Nicola, Buerlet, Stephanie, Pla, Marika, Reboul, Murielle, Lea, Nicholas, Chomienne, Christine, Thomas, Nicholas S.B., Mufti, Ghulam J. and Padua, Rose Ann (2007) Cancer Research, 67(18), pp. 8762-8771. ISSN (print) 0008-5472

, Padua, Rose Ann, Pla, Marika, Orr, Steven, Omidvar, Nader, Chomienne, Christine, Mufti, Ghulam J. and Rassool, Feyruz V. (2006) Molecular Cancer Research, 4(8), pp. 563-573. ISSN (print) 1541-7786

Brady, Nicola, , Cheung, Manyee, Mufti, Ghulam J. and Rassool, Feyruz V. (2003) Cancer Research, 63(8), pp. 1798-1805. ISSN (print) 0008-5472

, Mufti, Ghulam J. and Rassool, Feyruz V. (2002) Cancer Research, 62(10), pp. 2791-2797. ISSN (print) 0008-5472

, North, Phillip S, Brady, Nicola, Hickson, Ian D, Mufti, Ghulam J and Rassool, Feyruz (2001) Oncogene, 21, pp. 2525-2533. ISSN (print) 0950-9232

, Cebrat, Marek, Siemion, Ignacy Z and Kay, John E (1997) FEBS Letters, 418(1-2), pp. 224-227. ISSN (print) 0014-5793

Book Section

Shall, Sydney, , Farzaneh, Farzin, Curtin, Nicola and Mufti, Ghulam J. (2011) In: Tulin, Alexei V., (ed.) Poly(ADP-Ribose) Polymerase: Methods and Protocols. New York, NY : Springer. pp. 239-266. (Methods in Molecular Biology) ISBN 9781617792700

Conference or Workshop Item

, Carrett, Neil, Patel, Nishith, Kay, John and Siemion, Iggy (1995) In: Biochemical Society Transactions 656th Meeting; 11 - 15 Sep 1995, Dublin, Ireland. (Unpublished)

This list was generated on Sun May 19 06:33:02 2024 BST.